Returning to the city of her birth, Konta crushed Radwanska, 6-4, 6-2, to win her second career WTA title at the Apia International Sydney.
Radwanska beat Konta, ranked 10th in the world and already assured of climbing when the standings are updated on Monday, in the Briton's last final, in Beijing three months ago.
The Brit won her second Women's Tennis Association (WTA) title in a match that closed in two sets and lasted an hour and 20 minutes.
The 2016 Australian Open semifinalist took the opening set on a the strength of a single service break.
Radwanska admitted Strycova's marathon effort may have helped her on Ken Rosewall Arena.
"Well done Jo, it was unbelievable tennis today, I couldn't have played any better", she said.
Nintendo Switch Accessory Leak Shows PS4-Like Gameplay Recording Feature
Whenever Nintendo launches a new piece of gaming hardware, third-party manufacturers are very keen to support it with accessories. If you want to catch the news as it breaks, the Nintendo Switch event will begin at 11 pm ET / 8 pm PST on Thursday, Jan. 12.
"Normally you're thinking on the court that she can't play like this whole match and she going to have a couple of games where she plays worse". If she does to the great American what Heather Watson nearly did a few years ago at Wimbledon, her semi-final opponent could well be Radwanska.
A brilliant opening passing forehand victor from Radwanska, 27, suggested she was in the mood on Friday and when she was 0-30 up on Konta's serve in the second game of the match it looked as though it could be a tricky evening for the Briton. "I'm just very happy to make another final, especially here when it's always (a) very strong tournament".
The 25-year-old reached the semi-finals of the Australian Open last year - her best performance at a Grand Slam - and heads into the tournament next week as the ninth seed. The Czech finally got her long-awaited first hold of serve in the match after yet another tough game which got to deuce and allowed Strycova to get onto the scoreboard in the second set. She was soon 4-0 up and went on to serve out for the match after an hour and 22 minutes. "I feel like I'm getting back into the rhythm of things a little bit, but it's a long road". "I really felt I definitely maintained a high level throughout and I made it very hard for her to do much today".
Konta was being followed on court by Dan Evans, playing Russia's Andrey Kuznetsov in the semi-final of the men's event.