Leicester are seeking to overturn a 2-1 deficit from the first leg against Sevilla and Shakespeare says his players will approach the match with renewed self-belief.
Moreover, Leicester City have only lost four Premier League games at the King Power stadium and won all three of their Champions League games at home.
That defeat for Leicester prompted Claudio Ranieri's sacking and they have since beaten Liverpool and Hull City 3-1 under Craig Shakespeare, with Sampaoli, 57 on Monday, wary of improving opposition.
Sevilla looked magnificent in the first leg of this match-up with the 2-1 score line not serving justice to how good Sevilla performed.
A fascinating second leg is in store at the home of the Premier League champions, who have been revitalised as of late under the guidance of Craig Shakespeare.
The jocular coach was promoted from his role as assistant manager following Claudio Ranieri's shock dismissal last month, which he said left him feeling like a "pantomime villain".
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Even though we were favourites for the game, they did very well and there's nothing left but for us to congratulate them. "Right now we can only concentrate on Deportivo ".
Under Manuel Pellegrini last season City reached the semi-finals for the first time, losing to eventual champions Real Madrid 1-0 on aggregate, and De Bruyne is confident they can go further with Guardiola. We have practiced penalties and we try to leave no stone unturned.
The club's vice-chairman, Aiyawatt Srivaddhanaprabha, said: "Craig's skills as a coach and the high regard in which he is held by everyone the club were well known to us".
He has initiated the positive response we hoped change would bring'.
"Playing like this, we're going to struggle to go far in the Champions League, because you face the toughest games against opponents who don't afford you any mistakes", Sampaoli said.
"We knew by getting the away goal it gave us a great opportunity. We have asked him to continue to lead the team this season and we are very happy that he has accepted".
Defensive midfielder Nampalys Mendy will miss the Sevilla game due to a knee injury.