An Afghan commando stands guard at Pandola village, near the site of the USA forces' bombing in Achin district of Jalalabad, east of Kabul, Afghanistan, Friday, April 14, 2017.
Afghan officials claim 36 IS fighters were killed in the explosion.
The provincial government in a statement said at least four key leaders of the group were also among those killed.
The blast destroyed three underground tunnels as well as weapons and ammunition, but no civilians were hurt, Afghan and United States officials claimed.
The 30-foot-long, GPS-guided bomb is capable of destroying an area equivalent to nine city blocks.
The US hasn't provided any data on how many ISIS fighters were killed by the MOAB.
"This is not the war on terror but the inhuman and most brutal misuse of our country as a testing ground for new and unsafe weapons". "The strike was created to minimize the risk to Afghan and U.S. Forces conducting clearing operations in the area while maximizing the destruction of ISIS-K fighters and facilities", said the US Force.
Addressing a press conference in Kabul yesterday, he said the weapon used, the GBU-43, was created to destroy caves and tunnels and that this had been the "right weapons against the right target".
Also, as former Afghan President Hamid Karzai said in a tweet, quoted by the New York Times, the United States was testing its unused ordnance in Afghanistan (much as it had done in Iraq during the first Iraq war).
Mark Hamill: Carrie Fisher Star Wars tribute is 'therapy'
Earlier on Friday, Kennedy confirmed that The Last Jedi will be Carrie's last Star Wars film. "She's owned by them", he said. Disney CEO Bob Iger said in March that the filmmakers were "not changing (The Last Jedi) to deal with her passing".
White House officials won't detail precisely when that visit will take place but say it will come "soon".
In addition, said an administration official who spoke on the condition of anonymity, the attack also reinforces the message that US President Donald Trump has given his military commanders freer rein than did his predecessor, Barack Obama.
The assault came only a week after Trump ordered missile strikes against Syria in retaliation for a suspected chemical attack.
"The Mother of All Bombs" hit a mountainside in Nangarhar Province, eastern Afghanistan.
An Afghan resident living about a mile from where the bomb fell told CNN he heard an "extremely loud boom that smashed the windows of our house".
Rob O'Neill, the man who killed Usama bin Laden, said those who are questioning the use of the 21,000-pound ordnance are missing the bigger point.
The US army used the 9,800kg bomb, which weighs nearly as much as a double-decker bus, to target a tunnel complex used by the insurgents who are battling both the Afghan army and the Taliban in Afghanistan.
The region butts up against the porous Pakistan border. The Afghan Ministry of Defense said in a statement that several IS caves and ammunition caches were destroyed by the bomb. According to Afghan officials, the attack was able to decimate a deep tunnel of ISIS group.