The Englishman bagged a convincing 6-4, 7-5, 6-4 win over Djokovic and become first British player ever since Fred Perry to win Wimbledon men's singles championship.
The 30-year-old Scot, who is the top seed for the first time in his career at Wimbledon, is battling a niggling hip problem which forced him to withdraw from playing a couple of exhibition matches this week.
Murray's side of the draw would then see Nadal as the most likely opponent standing between the world number one and a place in the final.
Murray begins his title defence by opening the action on Centre Court on Monday against lucky loser Alexander Bublik, with the bottom half of the draw playing on Tuesday.
'I think it's going to be a really interesting Wimbledon, that's for sure, like it's been since the beginning of the year also.
Ivan Lendl, the world number one's coach, said: "Practice has gone well". He would have to be seriously injured not to play.
"I played unbelievably well", said Federer of his performance in final. Her first-round match should be interesting - it's against 18-year-old CiCi Bellis.
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"Depending how fit it is, if he's anything close to 100 percent physically, I consider him (Murray) one of the big favourites to win the tournament".
Thanasi Kokkinakis has a tough match against 29th seed and Juan Martin del Potro, while qualifier Andrew Whittington's first-round opponent is to be determined.
Djokovic, who is struggling to find form in the ongoing season, opens his campaign against Slovakia's Martin Klizan. The Spaniard, who is among the title favourites, might face seventh seed Marin Cilic or ninth seed Kei Nishikori in the quarter-final before a potential semi-final clash against Murray.
Nadal, who won Wimbledon in 2008 and 2010, has failed to make it past the fourth round at Wimbledon since he made the final in 2011, but this time the obstacles in Week 1 look surmountable.
Djokovic will start against big-hitting Martin Klizan, and then could face another power player in the third round: 2009 U.S. Open champion Juan Martin del Potro, who stunned the Serb at the Rio Olympics past year.
THREE-TIME champion Novak Djokovic has been bumped up to second seed for next week's Wimbledon championship despite slipping to fourth in the ATP world rankings while seven-times champion Roger Federer has also benefited.
And then, of course, Federer would be on a collision course with three-time champion and archrival Novak Djokovic in the semi-final.
Nadal is a two-time victor (2008 and 2010), while Djokovic has taken home three titles (2011, 2014 and 2015).