The mood Sunday at Camp Nou will be far different than it was three weeks ago at Hard Rock Stadium, where 66,000 fans cheered and sang during El Clasico Miami, a summer exhibition game between FC Barcelona and Real Madrid.
"This is to pay homage to all the victims of the recent terror attacks in Barcelona".
Less than 10 minutes later the 30-year-old then continued his duel with the Real Betis woodwork as an expertly taken free-kick was this time met by the left-hand post, but it would not be long before Barca's persistence was rewarded. The Barca need to play their game without Neymar, so Messi is under pressure to deliver the ball to the Betis net.
For the players, it will have been a relief to mark the occasion with a victory and also to return to winning ways after the two losses to Madrid - especially with Andres Iniesta, Gerard Pique and Luis Suarez all out. Barcelona are a quality side, but the absence of such quality players might have a huge impact.
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"We lost depth with Neymar's departure and we have to find a way to overcome that", Barcelona coach Ernesto Valverde said. Maybe I would have preferred to go to Barcelona another time. Here's the moment the diverse community came together to sing Michael Jackson's "We Are The World".
That lead should have been short-lived as Leon got through on goal, but the striker's hesitation enabled Javier Mascherano to get back with a remarkable challenge. "We have to find a way of playing that allows him to shine and his team mates too", said Barça coach.
Meanwhile, long-term absentee Rafinha Alcantara and Luis Suarez are also ruled out for the game against Betis, with the Uruguay worldwide expected to be out of for around four weeks due to a knee injury suffered in the Wednesday's defeat at the Santiago Bernabeu. They can not allow any opportunity for Betis to take advantage of any loose balls or careless defending.
The Catalan club also showed their support for those affected by the attack on Friday morning, with players and staff standing in a semi-circle at the club's training ground while holding a minute's silence. However, he should be even pleased if they manage to secure a point at Camp Nou, which has always been a hard place for away teams.