The quake comes just days after Mexico was hit by an 8.1 magnitude tremor, the biggest to hit Mexico in a century, killing at least 98 people.
The quake hit five miles from the Mexican state of Puebla, at a depth of 32 miles, according to the United States Geological Survey.
Thirty people died in Mexico City, the Associated Press reported, quoting the city government.
A major natural disaster has rocked the capital of Mexico, killing more than 216 people - at least 22 are believed to be children.
This is a breaking news story.
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The video is echoed by a number of others filmed across Mexico City as the terrifying quake tore through churches, hospitals and schools.
"Our priority at this moment is to continue with the rescue of those who are trapped and to give medical attention to those who are injured", Mexican President Enrique Pena-Nieto said.
Civilians as well as search and rescue teams went to work trying to find survivors using heavy machinery and bare hands to remove piles of rubble. It added that the U.S. Embassy in Mexico City is also ready to provide assistance to U.S. citizens who were possibly affected by the quake. "We are with you and will be there for you".
Early Wednesday, the director of Mexico's civil protection agency, Luis Felipe Puente, said on Twitter that 216 people had been killed. This is about 100 miles away, which means approximately 160 kilometers from Mexico city.
A firefighter and a rescuer search for survivors in Mexico City after a strong quake hit central Mexico on September 20, 2017. Until further notice, Mexico City's airport, schools as well as the stock exchange will remain closed. It came less than two weeks after another powerful quake caused 90 deaths in the country's south.