Nigeria became the first African qualifiers Saturday with a 1-0 Group B win over Zambia in Uyo thanks to a goal from another English Premier League player, Alex Iwobi of Arsenal.
Victory gave Egypt an uncatchable four-point lead over Uganda in Group E with one round of fixtures remaining.
Three more tickets are left to be picked by other African teams. Fans honking vehicle horns and waving Egypt's red, white and black flags took the streets across the country. "This is something you never witness in Egypt", said 23-year-old Gamal Mohamed in downtown Cairo's Tahrir Square, the iconic centre of the country's once-active protest movement, which has since been quashed by tough security measures.
But an energised stadium was flattened just minutes from full time when Bouka-Moutou ghosted in at the far post to slam a volley home past Egypt goalkeeper Essam El Hadary.
Turkish forces clash with Al Qaeda-linked rebels on border
Turkey's NTV , a private television station, reported an exchange of fire at the border area, quoting "military sources". Erdogan said Turkey would not desert civilians in Idlib and would not allow a "terror corridor" in northern Syria.
The game looked to be headed for a draw when Egypt were awarded a penalty.
Egypt have won four Africa Cup of Nations titles since 1990 - in 1998, 2006, 2008 and 2010 - but fallen consistently short in World Cup qualification.
But the Egyptians' World Cup hoodoo ended as Salah held his nerve late on.
Their Argentina-born coach Hector Cuper had admitted the pressure to end their absence had seen him take medication for high blood pressure.