The Gunners find themselves in the rare scenario of trailing their bitter rivals, with last season proving the first time in 22 years that Spurs finished above their neighbours in the Premier League. For what seems like the first time in decades, Tottenham is widely regarded as a clear favorite even though the match is taking place at Arsenal's Emirates Stadium.
With Spurs' injury problems I'm tempted to side with Arsenal at odds-against but it is hard to write off Tottenham with the likes of Denmark's hat-trick hero Christian Eriksen among their ranks.
It was a 24-hour period at the start of November that really drove home the reality that Tottenham, after decades of playing second fiddle to Arsenal, was the new dominant force in north London.
Most notably, of the eleven appearances Lacazette has made in the Premier League, two saw him coming off the bench - in the 4-0 defeat at Anfield and in the 3-1 loss against Manchester City the weekend before last.
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The Teenage Mutant Ninja Turtles however are more popular than Spawn, so this is certainly to make more fans happy. The fighting game debuts on Windows PC via Steam and the Microsoft Store on November 14.
On paper, Spurs are better than Arsene Wenger's side these days but the Gunners haven't slipped up at home in the League this season, winning all five of their fixtures.
"I think Tottenham is a good side but we have the quality to win this game and that is what we want to show".
Arsene Wenger has confirmed Arsenal will be looking to stop Harry Kane in particular on Saturday. They enter Saturday in danger of doing that for the first time this year, having also lost at Old Trafford on October 28.
But third-placed Tottenham, who have already beaten Real Madrid this season, will go in to the game full of confidence.
Dele Alli and Harry Winks, who also sat out England duty, will be assessed, along with Kane, on Friday.
Alexandre Lacazette was heralded as the saviour of Arsenal when he was brought into the club from Lyon during the summer.