Of course, there is a bright side to this new finding, and that is to limit your intake of ibuprofen.
The Danish research team warned: "Ibuprofen appears to be the preferred pharmaceutical analgesic for long-term chronic pain and arthritis".
Half the group took 600mg of ibuprofen twice a day - the maximum recommended dose in the U.S.is 800mg up to four times a day - for 2 weeks.
Aspirin, the best-selling NSAID on the USA market, was initially linked to stomach problems but was thought to be otherwise safe.
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The study is a continuation of previous research on pregnant women linking mild ibuprofen exposure in fetuses to an increased risk of inherited medical conditions, testosterone blockages, and physiological effects on the testicles of male babies. In addition to producing sperm, testicles secrete testosterone, the primary male hormone. The condition has been associated with an increased probability of reproductive, cognitive, and physical problems, as well as general mortality.
Before you go raid your medicine cabinet, Advil and Motrin are two brand names for ibuprofen. (In culture, there are no cells to produce luteinizing hormone to compensate.) The researchers found that a number of genes involved in steroid synthesis were affected by ibuprofen. This amount was used to represent the dose taken by athletes to manage pain. Hypogonadism is associated with impaired fertility, depression, heart failure, and stroke. "Ibuprofen is a very useful drug for acute pain conditions, its benefits have been well proven, but it is important to consider that hypogonadism may be an additional risk factor that people need to watch for when taking the drug for a long time", he said. LH's job is to stimulate the production of testosterone, so higher levels of LH without corresponding higher levels of testosterone could suggest an issue in the way the body's hormones are functioning. The other half took a dummy (placebo) tablet.
HollywoodLifers, did you know the negative effects of ibuprofen?
It's also not clear whether the same hormonal effects would be seen in men taking lower doses of ibuprofen, or whether the effects are reversible, particularly in men who take ibuprofen for long periods, study co-author Bernard Jégou, director of the National Institute for Research on Environmental and Occupational Health in France, told CNN.