Iran's Foreign Minister Javad Zarif tweeted, "US diplomacy sham is merely a regression to old habits: imprisoned by delusions & failed policies-dictated by corrupt Special Interest-it repeats the same wrong choices and will thus reap the same ill rewards".
"We will apply unprecedented financial pressure on the Iranian regime".
In his first major foreign policy address since moving to the State Department from the Central Intelligence Agency, the longtime Iran hawk and ardent opponent of the 2015 nuclear pact outlined an aggressive series of moves created to counter Tehran, which he called the world's top sponsor of terror. "Since the agreement was signed, Hezbollah has been armed by Iran, with Israel as the target", said the Secretary of State. Johnson said a "new jumbo Iran negotiation" would not be "very easy to achieve".
He warned that any entity conducting business with Tehran would be "held to account" by the USA, voicing hope that the new anti-Iranian sanctions will be met with support from USA allies beyond Europe.
There was, she said, "no alternative" to the agreement, which US President Donald Trump vowed earlier this month to abandon, and she said the European Union would stick by it if Iran met its commitments. Pompeo said that the long list of demands was Iran's fault, and that crippling sanctions would bring them back to the negotiating table.
The new USA demands are so intrusive and broad that Iran's rejection of them seemed all but certain even before Rouhani spoke.
In a speech delivered on May 21, US Secretary of State Mike Pompeo laid out 12 demands that Iran has to fulfill in order to negotiate another nuclear deal with Washington.
The Trump administration, two weeks after it withdrew from an worldwide arms control deal that curbed Iran's nuclear ambitions, called Monday for a new global coalition to force the Islamic Republic to capitulate to a long list of political and military demands. In that crisis, the administration says it won't accept a strategy of synchronized, step-by-step concessions in exchange for North Korea gradually giving into demands to give up its nuclear program.
Limiting Iran's missile capabilities was one of Pompeo's main demands, as the Iranian military has carried out a series of ballistic missile tests in recent years. A new pact should require that Iran stop enrichment of uranium, which was allowed within strict limitations under the previous deal.
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First and foremost, it is highly crucial for Iran that the Europeans keep buying oil from the country - now around 700,000 barrels per day (bpd) or roughly 40% of overall Iranian oil exports.
The deal was agreed between Iran and the five permanent members of the UN Security Council - the US, UK, France, China and Russian Federation - plus Germany.
Many European officials, including those who negotiated the Iran agreement alongside the United States, have chafed at the Trump administration's positions on Iran, the Paris climate accord, moving the US Embassy in Israel to Jerusalem, and trade tariffs. The leaders in Tehran will have no doubt about our seriousness.
"Iran will never again have carte blanche to dominate the Middle East", Mr Pompeo said.
"Europe wants to find a way to work with us, and if you give them a little bit of opening they'll take it, but there's no opening here", said Jarrett Blanc, a senior fellow at the Carnegie Endowment for International Peace and a former State Department coordinator for Iran nuclear implementation.
Pompeo will present the approach during a speech Monday at the conservative Heritage Foundation.
Asked how the US will work with European nations to ease the impact of sanctions on their companies, Pompeo gave no ground. Now Washington's European allies want to stick with the existing deal.
Soon after the speech, a member of the Iranian parliament's national security committee called Pompeo's strategy nothing more than "U.S. dreams" and suggested the best thing to do was to wait for a change in position after Trump leaves office, whenever that may be.