Williams was competing in her first grand slam final since she took maternity leave to give birth to her daughter after winning her last honour in Melbourne at the 2017 Australian Open.
Kerber said of her win: "It's just a dream come true". "Angelique played really well". And leading the list is her husband Alexis Ohanian.
The 30-year-old German lost to Williams in the 2016 Wimbledon final. I'm not going to ever make an excuse.
'I'm just me, that's all I can be.
It is a message that resonates with women in countless arenas, not just sports.
Williams fell short in her bid to tie Margaret Court's record of 24 grand slam singles titles, as Kerber's fierce defence and pinpoint accuracy earned her a third major trophy. She then followed it up with what was, by her standards, a miserable 2017.
Serena Williams is projected to rise from 181 to 28 in the WTA rankings. She played unbelievable today. "When I retired it didn't even cross my mind - the possibility of coming back". I think two weeks ago nobody expected I can go so far. Get that desire back? "Serena is showing you can do it".
So, despite her straight-sets defeat in the final to Kerber, who's winning a Grand Slam after 22 months, Serena has done incredibly well.
Williams tried everything to get back into the match but her afternoon was rather summed up by the drive volley she placed over the baseline in the final game after a stunning rally.
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Men's semifinals: Novak Djokovic beat Rafael Nadal 6-4, 3-6, 7-6 (9), 3-6, 10-8, completion of suspended match.
"Honestly I feel like if I can do it, they can do it".
Williams battled it ou with 11th-seeded Angelique Kerber.
Now she's dropped another.
Strong, fit and determined, Kerber wasn't rattled by Williams' powerful groundstrokes.
The American is just 14 matches into her comeback after more than a year off on maternity leave and says while her priorities have changed, her hunger remains undiminished.
Earlier this month, Williams revealed she "cried" when she missed her daughter's first steps. Her dominance before pregnancy might, for some of us, take away the weight of her journey to the final. "It's obviously disappointing, but I can't be disappointed".
"It was such an incredible tournament for me", a teary Williams said.
"I just feel like to tell all the mums, like I had such a long struggle to come back and it was really hard and honestly I feel like if I can do it, they can do it".