City added a second six minutes later through Jesus, who was perfectly placed to drill a shot into the bottom corner from 20 yards after Benjamin Mendy had been prevented from entering the penalty area.
Huddersfield, who were without Ryan's Australia teammate Aaron Mooy because his wife Nicola was going into labour, were never likely to replicate last season's feat of stopping City scoring at home.
Of course, with so long left, it was nearly inevitable that the Blues would inflict further damage and it came on 75 minutes as Mendy sent in a fine low cross and Aguero deftly volleyed past Hamer from close range for yet another hat-trick in sky blue.
With no Kevin De Bruyne for the next three months, it seems like City may be able to cope just fine without their magic attacking midfielder. After all the neat passing, Aguero's 25th minute opener came from a 70-yard clearance from goalkeeper Ederson, before cleverly chipping Hamer.
Kongolo turns it into his own net, but that goal was all Leroy Sane! 6-1.
It is understood City bosses have not been approached by Spurs about the problem and have had no dialogue.
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Manchester City will be disappointed if they don't roll over Huddersfield, who looked dire in their opening match.
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Wagner went ultra-defensive with his side holding a line of five defenders on the edge of the box and another five midfielders holding another line in front of them. It's part of the game, but the lies are something that I really don't like.
Former Man City man Aaron Mooy will have a point to prove against his old side. The Australian is one of the few players capable of making a pass under pressure and his composure was missed in the centre of the pitch.