Her older sister, Venus, who defeated Camila Giorgi in straight sets.
The 2000 and 2001 champion in NY will face Serena for a place in the last 16 if the six-time victor gets past Germany's Carina Witthoeft under the Arthur Ashe Stadium lights later in the day.
Venus won their second round clash in Australia in 1998 but Serena, bidding for a record-equalling 24th Grand Slam title, has built up an advantage over the last two decades, enjoying a 17-12 head-to-head superiority.
You can catch her in action in a Round of 32 match on Friday where she will meet her sister, Venus Williams, in an all-Williams showdown. I'm sure they (Serena and Venus) will hate it but I think it's going to be handsome for tennis.
"At least this time, " Venus told the crowd, "it'll be fair".
The reason this match comes so early is that their rankings are not what they've been in the past.
Hurricane's wind, rain pounds Hawaiian islands
A number of structures on the island of Hawaii were destroyed, said Melissa Dye, a Weather Service spokeswoman in Honolulu. Hurricane conditions, including winds of at least 74 miles per hour , will start there Friday, the Hurricane Center said .
"The best part is we bring out the best in each other", Williams added. Obviously I wish I could have been playing a little bit better.
"If I would say my true feelings, it would be bleeped out, because it was ridiculous", said Azarenka. "Whatever, it will work". "I know the same thing is for her". The No. 31 seed Verdasco took down the world's former No. 1 in four sets, beating Murray, 7-5, 2-6, 6-4, 6-4, in the second round.
Cornet said she was stunned that the furor had caused so much controversy and was happy to accept the USTA's apology.
Ukraine seventh seed Elina Svitolina was also an early victor on Wednesday, cruising past Tatjana Maria 6-2, 6-3 to avenge a first round defeat at the hands of the German player at Wimbledon last month.
"I felt the energy, definitely", Venus said. "Every year it's such a tough field in Wuhan so I'll be ready to compete hard amongst some really great players". Julia Gorges, meanwhile, found herself upset by Ekaterina Makarova in straight sets.
Top-seeded Rafael Nadal was in dominant form in his late-night match, winning 46 of 55 first-serve points to wear down Vasek Pospisil 6-3, 6-4, 6-2.