"Each new round of sanctions proves our foe's complete lack of success in pressuring Russian Federation with previous such attempts", said Ryabkov, who added that Washington would never succeed in dictating its conditions to Moscow.
"We see the fervor gripping USA politicians, and many of them are held hostage to their beliefs about their "exclusiveness" and hope that if they crank pressure up just one more notch, they will be able to dictate their terms to Russian Federation", he elaborated.
In Moscow, Russian member of parliament Franz Klintsevich said the sanctions would not affect the S-400 and SU-35 deals.
These "malign acts" range from Russia's annexation of Crimea and its participation in the Ukrainian and Syrian wars, to its meddling in the 2016 presidential election.
The punitive measures are part of China-related "hysteria", over Beijing's ever-growing economy, which is now sweeping Washington, author and historian Gerald Horne believes.
In a Thursday statement, the US State Department said that the sanctions had been invoked under Section 231 of Countering America's Adversaries Through Sanctions Act of 2017 (CAATSA) "for engaging in significant transactions with persons on the [List of Specified Persons]".
The sanctions freeze any of EDD's and Li's assets in U.S. jurisdictions.
But the arms lobby in USA also appears intent on using this opportunity to wean New Delhi away from Russian armaments and make a pitch for United States arms, even as officials assure that sanctions are not meant to undermine the defense capabilities of any country.
Sergei Ryabkov, deputy foreign minister, warned that the US was "playing with fire". "They are instead aimed at imposing costs upon Russian Federation in response to its malign activities", he said.
Christine Blasey Ford's high school classmate: Controversy has felt 'personal'
Ford, whose identity was unknown until Sunday, had sent a letter to Democratic Senator Dianne Feinstein in July. Women knew about it happening in the workplace, but it wasn't a big issue. "And it is not the woman's fault".
United States officials said that the U.S. could consider similar action against other countries taking delivery of Russian fighter jets and missiles.
"Each new round of sanctions proves our foe's complete lack of success in pressuring Russian Federation with previous such attempts", Ryabkov said according to the Reuters news agency.
Collin Koh, a security analyst at Singapore's S Rajaratnam School of International Studies, said the sanctions would do little to counter the evolving research and development relationship between China and Russian Federation.
"We will continue to vigorously implement CAATSA and urge all countries to curtail relationships with Russia's defense and intelligence sectors, both of which are linked to malign activities worldwide", the State Department said.
For many years, China was Russia's biggest military client, relying on Moscow for advanced weapons and adapting some of the technology for its own systems. He also said Moscow needed Chinese money and Beijing wanted advanced military technology.
The economic sanctions are "chiefly due to the fact that we produce large volumes of competitive products", Russia's trade minister, Denis Manturov, told reporters.
"This is a significant step", the administration official said.
"As to other potential recipients of the S-400, we haven't made any determinations yet with respect to what to do about those, but you can be confident that we have spent an enormous amount of time talking about prospective purchases of things such as S-400s and Sukhois with people all around the world who may have been interested in such things and some who may still be", an administration official told journalists on background.
Washington has expressed concern that Turkey's planned deployment of the S-400s could pose a risk to the security of some US -made weapons and other technology used by Turkey, including the F-35 fighter jet.