It includes midfielder Ruben Loftus-Cheek, a player who has only played 22 competitive minutes for his club Chelsea since appearing at the World Cup for the Three Lions.
Shaw endured a tough 2017-18 season, facing public criticism from United manager Jose Mourinho, who questioned his approach to training and commitment to the club.
However, there's still no place for the likes of Joe Hart, Chris Smalling and Jack Wilshere.
"There's a point where I don't need to know what those guys can do as we're looking to bring younger players through".
Explaining his selections, Southgate said: "We're obviously coming off the back of a successful summer, so I think there's a good foundation for us to build on".
Manchester United defender Luke Shaw is set to be recalled to the England squad for next month's games against Spain and Switzerland, sources close to the player have told ESPN FC, with Old Trafford teammate Ashley Young missing out.
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Otherwise, Southgate placed his trust in the players who defied expectations in Russian Federation as England reached the semifinals for the first time since 1990.
"With us only being three games into the (domestic) season, I felt some continuity was important".
"I want us to try to capture what we had this summer", said Southgate.
In an interview with The Sun, Martin Keown has said that he was left impressed by Luke Shaw when he first saw him playing for Southampton as a 16-year-old.
"You see a lot of things in the media that go on about what our dressing room is like, but we have a really good spirit, a really good group of lads who want to work and achieve big things here". It was great that we were able to have mature conversations about that. "The door's certainly not closed".
The England global, who has been called up to the Three Lions' squad for next month's double-header of fixtures, is out of contract at the end of this year.