Four people were killed by rising waters in Florence's wake, the sheriff's office said.
The National Weather Service issued a flood warning for the Waccamaw River in Conway, which was already at 13.5 feet above flood level on September 19, and was expected to rise by 1.5 feet a day starting September 20.
Officers say it appears the water knocked the man's auto off the roadway.
Almost 3 feet of rain fell in some parts of North Carolina and almost 2 feet in areas of SC.
North Carolina Agriculture Commissioner Steve Troxler, who conducted an aerial survey of damage on Tuesday, said the flooding has affected the top six agricultural counties in the state. Though the hurricane packed 90 miles per hour (145 kph) winds as it came ashore, the amount of water Florence pushed ashore and dropped inland has swamped vast areas still vulnerable to rising rivers. That breaks a rainfall record for tropical cyclones in North Carolina of just over 2 feet (60 centimeters) set by Hurricane Floyd in 1999, according to the National Hurricane Center in Miami.
What made the situation worse was Florence's languid, 6 kph pace, and its proximity to the coastline which provided the storm access to an unlimited supply of water vapor from the warm Atlantic Ocean.
"Although the winds are gone and the rain is not falling, the water is still there and the worst is still to come", said South Carolina Gov. Henry McMaster.
Wilmington, on the banks of the Cape Fear River in North Carolina, was nearly completely cut off by land but emergency management teams managed to truck food and water overnight into the port city of 120,000 people.
On September 10, 2018, the National Hurricane Center warned the residents of Virginia and North and SC that the fast approaching tropical storm Florence was gaining strength and could make landfall as a Category 5 hurricane.
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The crisis is slowly moving to SC, where there was enough warning and certainty about where the water was going that hundreds of people loaded furniture from their homes into trucks and flatbeds to take to higher ground.
At least 36 people have died as a result of the storm, according to CNN.
The two deputies escaped the vehicle but were unable to open the doors to get the women out, authorities said.
More than three dozen flood gauges in North and SC showed flooding, according to the National Weather Service.
"People in flood prone areas or near waterways need to remain alert as rivers crest and stay above their banks in coming days", Cooper said.
"I think he just said have a good time!" the reporter gasped.
In a phone interview Friday, Kinlaw estimated 100 people were evacuated Thursday night and that about 50 people remain in the town.
Traveling with him were the four USA senators from North and South Carolina, Office of Management and Budget Director and former South Carolina Rep. Mick Mulvaney, and Homeland Security Secretary Kirstjen Nielsen. "The footprint of flooding from this storm covers much of the same area hit by flooding from Hurricane Matthew in 2016, which only worsens the burden on these farmers".
In South Carolina, the flood was far from over.