The magic numbers drawn Tuesday night were 5, 28, 62, 65, 70, and the Mega Ball was 5.
State lottery officials announced Wednesday that the winning ticket was sold at KC Mart #7 at 303 Lee Vaughn Road in Simpsonville.
The other winning ticket in MA has not yet been claimed.
The world may never know who the victor is, however.
Tickets for the Mega Millions draw are sold in 44 US states, the District of Columbia and the US Virgin Islands and there had not been a top prize victor since July.
The buyer of the ticket beat the odds of 1 in 303 million to win the Mega Millions drawing for one of the largest jackpots in U.S. history.
The victor would only become an actual billionaire by taking the prize in annual installments over three decades and hanging on to the bulk of the money. The lump sum cash payout is estimated at $354.3 million.
But unfortunately for the players, the jackpot was won by a ticket bought in SC this morning and none of the above became a billionaire today. And the public may never find out. That is what most lottery winners do. "Take a deep breath and enjoy the moment!"
The prize is extraordinary by any measure, but particularly so for SC.
It's about as much as 20 percent of the $8 billion that state lawmakers have to spend each year.
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She continued, "I've never been a "pc" kind of person - but I understand that we do need to be more sensitive in this day and age".
Earlier estimates had said this week's Mega Millions game would be the largest lottery jackpot ever.
Sales from this drawing generated more than $10 million for state beneficiaries, which include more than $4 million for environmental causes.
"It's a big, big win for South Carolina", Cooper said.
But when the jackpot was finalised, it was downgraded to US$1.537 billion.
The jackpot was the second largest in the history of Mega Millions drawings.
"Estimates are based on historical patterns", said Carol Gentry, a spokeswoman for the Maryland Lottery, which leads a consortium of state lotteries participating in the Mega Millions jackpot in a phone interview this morning with The Associated Press.
"There are few precedents for a jackpot this size".
One of the MA winners was Jennifer Santo, 40, of Dartmouth. Winners have up to 180 days to come forward to claim their money. And it is enough money for the victor to give more than $300 to each of South Carolina's 5 million people.
CJ Patel is the owner of KC Mart No. 7 in Simpsonville.