The Los Angeles Police Department said on Twitter that the department didn't receive any reports of damage, adding that "This was a strong one and a good reminder to be prepared".
Veteran seismologist Lucy Jones says the natural disaster Thursday was the strongest to hit Southern California in 20 years.
An quake struck in California on July 4, initially measuring 6.6 magnitude but later being revised down to 6.4.
A tsunami is not expected, according to the National Tsunami Warning Center.
Southern California has been rocked by a magnitude-6.4 natural disaster, the US Geological Survey (USGS) said, with authorities warning that the tremor, the largest in two decades, might not be the day's last.
The quake struck about 150 miles northeast of Los Angeles shortly after 10:30 a.m.
Early reports show broken bottles in stores, merchandise littering store floors and some fires.
Consequently, Diane Ruggiero, general manager of the Hampton Inn and Suites Ridgecrest in Ridgecrest, tells CNN that the hotel suffered some significant damage.
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The moderately large shaker was felt over a wide area from Orange County to Las Vegas.
The United States Geological Survey (USGS) reports the source of the quake in Searles Valley near Ridgecrest with a depth of 8.7km. A number of buildings in the county suffered minor cracks but there were no immediate reports of injuries.
This morning's temblor, which was felt as far as Los Angeles, was quickly followed by several smaller aftershocks in the area.
The Los Angeles County Sheriff's Office said there was "shaking and rolling" in the county.
A magnitude 6-4 natural disaster was felt throughout the Southland Thursday, shaking up local residents celebrating the Fourth of July. "Operations remain normal", it tweeted.
"My sister was in the house and my dog, so we just got everyone outside and then it ended".
Within the next few days, there's a 1 in 20 chance of a larger quake than the main temblor - the same likelihood as with any other quake, she said.
By now, most attractions have since reopened with no damage reported, although we're sure the squirrels are still quite shocked.