On Saturday, Swiss second seed Federer eased past French 27th seed Lucas Pouille 7-5, 6-2, 7-6 (7/4) and will face Italy's 17th seed Matteo Berrettini for a place in the quarter-finals.
While the Ipswich-born star isn't looking ahead to potential clashes, a win on Monday could set up a quarter-finals match against seven-time Wimbledon victor Serena Williams.
Eight-time Wimbledon singles champion Roger Federer posted yet more landmarks on Saturday as all the main contenders male and female encountered few problems in reaching the Last 16.
The third issue was a slow burner triggered by seven-times Wimbledon champion Serena Williams, who appeared surprised to be informed Barty was top of the world rankings in her pre-tournament news conference.
Nadal, who embraced Tsonga fondly at the end in stark contrast to the chilly handshake he had with fiery Australian Nick Kyrgios in the previous round, said he was delighted with the manner of his victory describing every match as a battle.
"Serena hasn't been at numerous tournaments lately so it's not really something that I worry about", she said.
Berrettini saved three match points to see off Diego Schwartzman of Argentina 6-7 (5/7), 7-6 (7/2), 4-6, 7-6 (7/4), 6-3.
An entertaining match might have enthused the two-time champion in more ways than one as the contest dragged on in draining fashion until Sousa won 4-6 6-4 7-5 4-6 6-4 in three hours and 56 minutes, becoming the first-ever Portuguese player to reach the last 16.
Former Patriots linebacker Tedy Bruschi suffers stroke
"Tedy has the complete support of ESPN and we wish him a speedy recovery", the network said in a statement to TheWrap on Friday. He and his family later launched Tedy's Team, a running club that raises money for the American Stroke Association.
Czech sixth seed Kvitova defeated Poland's Magda Linette 6-3, 6-2 and will face either Britain's Johanna Konta or Sloane Stephens of the United States for a place in the quarterfinals.
She was powerless to stop the Queenslander charging through the first set, but at least managed to salvage a consolation game as she succumbed 6-1 in just 25 minutes.
When Goerges soaked up everything Williams could throw at her to fight back from 0-40 down and hold her serve in the second game of the opening set, it seemed this might be another long day.
Williams and Barty first met when the Australian was a teenager at her home slam in 2014.
"That was really good", said Barty.
"I'm getting a really late start (in all of my matches here so far, but) all that matters is that I am still here".
Following his match, Federer said that it is hard for a younger player to win Grand Slams.
"It's such a buzz going around about me and Andy now, that I've got nervous".
'Really, I just need to go about it, be really simple, make up my mind, pick my spot, hit it, and try and bring a very simple mindset and have this real clarity around how I want to play, but also knowing I have the ability to adapt and play a different shot if I need to'.