If she is to be confirmed as commission president, Ms Von der Leyen needs to win the backing of a simple majority of 50% plus one of MEPs.
The minister has said she will resign her portfolio regardless of the outcome of Tuesday's vote "in order to serve Europe with all my strength". If she gets fewer than 400 votes, she might face a challenge to her ability to lead the European Commission which could see her being rejected as the next President.
Earlier July, von der Leyen, current German defense minister, was nominated by the leaders of the EU member states to replace the current President of the European Commission, Jean-Claude Juncker.
"Parties other than [the conservative European People's Party] agreed not to give a "blank check" to von der Leyen, she said. "It is thanks to you, and to all the other European icons, that I present to you today my vision of Europe".
The vast majority of Renew Europe, previously known as the liberal Alde group, is also said to have backed von der Leyen following her speech.
Earlier in the day, von der Leyen had issued a wide array of policy promises in a speech ranging from climate change to youth job creation.
In Strasbourg, Nigel Farage, the Brexit Party leader, accused Mrs von der Leyen of wanting to build "a centralised, undemocratic, updated form of communism where nation state parliaments will cease to have any relevance at all".
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"I think an extension could really only happen if it were to facilitate something like a general election in the United Kingdom, or even something like a second referendum, if they made a decision to have one", Varadkar said. "Those are the two biggest concerns or opportunities we have to tackle", she said. She pledges to be more ambitious when it comes to 2030 targets to reduce carbon emissions as part of the fight against climate change.
But Von der Leyen's role also Germany's defense minister was plagued with controversy, as reports detailed fleets in need of fix, personnel shortages, as well as stolen and missing weapons - and, despite boosting German defense spending during her tenure, she still did not manage to modernize the country's armed forces.
She was born as Ursula Gertrud Albrecht on October 8, 1958 in Brussels, where her father Ernst Albrecht worked as a senior European Commission official, and lived there until age 13.
"I want Europe to become the first climate-neutral continent in the world by 2050", she said, adding she would work out "a green deal for Europe in the first 100 days" of her office.
After returning to Germany, von der Leyen got involved in local politics.
"She absolutely wants the European Union to expand, she wants foreign policy to take place without any nation state having a veto".
The Withdrawal Agreement negotiated with Theresa May's administration by Michel Barnier "provides certainty where Brexit created uncertainty", she said.
"However, I stand ready for a further extension of the withdrawal date, should more time be required for a good reason", the former German Defence Minister added to catcalls from Brexit Party MEPs in the chamber. He said her version for Europe would centralize power to the point where national parliaments would no longer matter.